Unlock Precise Chemical Insights with Sirius T3

Discover the power of the Sirius T3, the gold standard in automated titration and partitioning analysis. Whether you’re in drug discovery, chemical research, or formulation development, Sirius T3 delivers accurate and reproducible measurements of critical physicochemical properties.

What Sirius T3 offers:

• Precise pKa determination to understand ionization behavior

• Reliable logP/logD measurement for predicting compound lipophilicity

• Automated, high-throughput workflows for maximum efficiency

• Robust data to accelerate your R&D decisions

Peer-reviewed publications

Spielvogel CP, Schindler N, Schröder C, Stellnberger SL, Wadsak W, Mitterhauser M, Papp L, Hacker M, Pichler V, Vraka C. Enhancing Blood-Brain Barrier Penetration Prediction by Machine Learning-Based Integration of Novel and Existing, In Silico and Experimental Molecular Parameters from a Standardized Database. J Chem Inf Model. 2025 Mar 24;65(6):2773-2784. doi: 10.1021/acs.jcim.4c02212. Epub 2025 Mar 4. PMID: 40036481; PMCID: PMC11938273.

Schwarzinger J, Adelsberger S, Ortmayr K, Stellnberger SL, Tahir A, Hädrich G, Pichler V, Rollinger JM, Grienke U, Dailey LA. Biopharmaceutical profiling of anti-infective sanggenons from Morus alba root bark for inhalation administration. Int J Pharm X. 2024 Aug 5;8:100272. doi: 10.1016/j.ijpx.2024.100272. PMID: 39252692; PMCID: PMC11381475.

Stellnberger SL, Harvey R, Schwingenschlögl-Maisetschläger V, Langer T, Hacker M, Vraka C, Pichler V. Investigating experimental vs. Predicted pKa values for PET radiotracer. Eur J Pharm Biopharm. 2024 Oct;203:114430. doi: 10.1016/j.ejpb.2024.114430. Epub 2024 Aug 3. PMID: 39103001.